If your browser home page url becomes about:blank and you always see some unwanted page, you have a spyware infection called CoolWWWSearch. The unwanted home page depends on which variant of the CoolWWWSearch spyware you have....there's about 30 variants that do pretty much the same thing.
I had the same as yours, about:blank and Home Search. The variant name is CoolWWWSearch.HomeSearch. I think I've gotten rid of it, now.
You will need Adaware, Spybot, and a free tool called CWShredder.exe from www.majorgeeks.com. Adaware and Spybot can only remove the infected files. CWShredder does the real work.
Here's what to do :
1) run CWShredder. First off, Scan Only and you will see a list of the CoolWWWSearch variants on your PC. Then select Fix and CWShredder will drop a train on anything running. CWShredder should automatically reboot your system.
2) run CWShredder again after rebooting. Things should look clean when you Scan Only.
3) Check for Problems with Spybot Search and Destroy. Have it remove everything it comes up with.
4) Do a Full System Scan with Adaware. Again, quarantine anything it comes up with.
Things should be fine at this point, but run #5 for good measure
5) Reboot and rescan with all 3 tools. If all is good, they will come up with nothing.
At no time during this process should you start your web Browser. If the spyware is not totally removed, it will completely reinstall itself when the browser is launched.
When this thing is gone, I strongly suggest turning up the security with Spybot and using its "Immunize" feature to block all known rogue sites, tracking cookies, etc.