To correct RE2 compatibily/saving problems:
step 1: Uninstall WinXP Service Pack 2
step 2: right-click on RE2 shortcut and select 'Properties', select 'Compatibility' tab, and choose Windows 95, then press Enter.
step 3: right-click on blank space of the Desktop and select Properties, select the Settings tab and click on the Advanced button, select the 'Troubleshoot' tab and drag the arrow 2 times to the left
Press enter and close 'Display Properties'
step 4: open Windows Media Player and just leave it running.
You can now start playing RE2
Notes:
*Compatibility mode for RE2 cannot work if WinXP Service Pack 2 (or greater) is installed.
*If you ignore step 4, the game will run very slowly.
*After you finished playing the game, you should reset the arrow on step 3 to 'Full accelerations'
*Everytime you start RE2, you should verify that you have done step 3 and 4