This is how I got Nuclear strike to work under WIN XP.
Load CD. Autorun immediately starts the program launcher. Exit from this, I could not get it to work.
Open the CD and run ins.exe. This loads the game to C:\NUKEPC.
Track down a glide emulator called dgVoodoo. I got version 1.4 from here http://dege.freeweb.hu/
Download to a spare folder & run dgVoodoosetup.exe
THis creates a new folder called dgVoodoo1.40plus
Run dgVoodoo.exe
Copy the files from this folder to C:\NUKEPC. Probably don't need them all copying but that's what worked for me
In C:NUKEPC run NUKEPC.exe
Works fine with keyboard or joystick ( I have MS Sidewinder and it was automatically detected & set up)
Could not get it to work with mouse.