Hi! I have a Windows Vista 64bit, with Intel Dual Core and nVidia GeForce 9600GT, and yes, I've managed to play Resident Evil 2 with no problems whatsoever (I could save the game normally and rum the game withouth that annoying graphical weird lines glitch).
Here's how I managed to do this:
- Tried to do the full install but, in my case, I couldn't install the core files (could only install "Sound and Leon's/Claire Data"). Therefore, I couldn't update the game to 1.04, meaning that you won't necessarily need the patch to correct things up;
- I'd installed the game in the default directory (I don't know if it had to be necessarily done to avoid problems, though);
- Then, to run the game, I had to change the Windows color depth from 32bits to 16bits (in "Video Settings");
- And here's the catch: in the second option of the launcher, when you set your graphic card manufacturer, I choose "3D Rage Pro", and that solved the weird lines graphical glitch.
And that's all.
Note that, in my case, I didn't need to turn off anything from my video card control panel (not even anti-aliasing or anisotropic filter).
If the "3D Rage Pro" option does not resolve the weird lines glitch, keep trying with other video cards: probably you'll find one that will correct the problem.
Hope this helps you to play this great game!!
