Hii,
I work on many OS Vista , Win 7,XP and have installed the combo of Macfee & Advanced System Protector , the reason of using Advanced System Protector is that it not only blocks the spyware b4 it can enter your system, will also clean the infections if any and it gives routine updates of the latest definitions and is very easy to use.The On Execution Scanner & Alert Shields make it more efficient in the case of internet access. free version of ASP is also available which provides free scanning and cleaning.
Try this.
http://www.systweak.com/AntiSpyware/Download/