I have a similar problem. I too am running xp with two drives, a creative dvd and a plextor 1210a and i also use nero as my burning software. My problem is that none of the cds I write with the plextor/nero could be read by the dvd drive. I have to use the plextor to read the cds I burn with it, whether data or audio cds. Funny thing is the audio cds can be read by my cd players, both my discman and home audio cd player. I havent tried having an ordinary cd rom read the cds i burn with the plextor, but I will try it tomorrow. I only noticed this problem this week. The other cds I burned before this are readable by my dvd drive. the last software i remember installing before this happened was freemp3, it's a utility to make the media player xp capable of ripping cd's to mp3. I uninstalled it already but I still have the same problem. And another thing, my brother runs xp also with a 1210a plextor and an asus dvd drive and he has the same problem as me. Any ideas?